منابع مشابه
Hepatic Dysfunction Caused by Consumption of a High-Fat Diet.
Obesity is a major human health crisis that promotes insulin resistance and, ultimately, type 2 diabetes. The molecular mechanisms that mediate this response occur across many highly complex biological regulatory levels that are incompletely understood. Here, we present a comprehensive molecular systems biology study of hepatic responses to high-fat feeding in mice. We interrogated diet-induced...
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BACKGROUND Daming capsule (DMC), a traditional Chinese formula, has a lipid-modulating action with reduced adverse side effects as compared with other lipid lowering compounds. Since endothelial dysfunction often accompanies the hyperlipidemic state, we hypothesize that DMC might restore endothelial dysfunction produced by a high-fat (HF) diet. Importantly, we also investigate possible mechanis...
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Curcumin, a type of natural active ingredient, is derived from rhizoma of Curcuma, which possesses antioxidant, antitumorigenic and anti‑inflammatory activities. The present study aimed to investigate whether treatment with curcumin reduced high‑fat diet (HFD)‑induced spermatogenesis dysfunction. Sprague‑Dawley rats fed a HFD were treated with or without curcumin for 8 weeks. The testis/body we...
متن کاملHigh-fat diet aggravates postoperative cognitive dysfunction in aged mice
BACKGROUND Silent Information Regulator 1 (Sirt1) and apoptosis play key roles in postoperative cognitive dysfunction (POCD). Consuming a high-fat diet (HFD), a prevalent type of diet in modern society, has been increasingly recognized as contributing to neurodegenerative diseases. Although Sirt1 and apoptosis are significant responders to HFD in the brain, little is known regarding the functio...
متن کاملArterial endothelial dysfunction in baboons fed a high-cholesterol, high-fat diet.
BACKGROUND Endothelial dysfunction signals the initiation and progression of atherosclerosis. Elevated LDL-cholesterol concentrations have been suggested to induce endothelial dysfunction, but direct in vivo evidence for the relation is still lacking. OBJECTIVE We examined the hypothesis that a high-cholesterol, high-fat (HCHF) diet can directly cause endothelial dysfunction in vivo. DESIGN...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2015
ISSN: 1552-5783
DOI: 10.1167/iovs.14-16143